Furthermore, even if a method that can theoretically encompass and effectively and systematically sample all the conformational combinatorial space that can be generated by permutations at the gene level was made practical, such method would not be able to account for the myriad of random mutations which are observed or could occur in antibodies. It is evident that at the current computational resources, the feat of defining the entire conformational combinatorial space multiplied by sequence permutation space, even if down-scaled by canonical conformations and amino acid sequence permutation limitations set at the gene level, and then attempting to rate each of the inhabitants of that space according to binding affinity, is impractical if not impossible. G16C20/60- In silico combinatorial chemistry.ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures G16C- COMPUTATIONAL CHEMISTRY CHEMOINFORMATICS COMPUTATIONAL MATERIALS SCIENCE.G16B35/00- ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides.G16B20/30- Detection of binding sites or motifs.G16B20/00- ICT specially adapted for functional genomics or proteomics, e.g.G16B15/30- Drug targeting using structural data Docking or binding prediction.structural or functional relations or structure alignment G16B15/00- ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g.INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY G16- INFORMATION AND COMMUNICATION TECHNOLOGY SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS.filed Critical Yeda Research And Development Co. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority claimed from US201462021309P external-priority Application filed by Yeda Research And Development Co. Priority date (The priority date is an assumption and is not a legal conclusion. Inventor Sarel Fleishman Gideon LAPIDOTH Maria Gabriele PSZOLLA Christoffer NORN Original Assignee Yeda Research And Development Co. Google Patents WO2016005969A1 - Method of computational protein design WO2016005969A1 - Method of computational protein design
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